Partner Profile

Organization name: 

Gr. T. Popa University of Medicine and Pharmacy, Iasi, Romania (UMF Iasi) 

 

Identification information:

Gr. T. Popa University of Medicine and Pharmacy, Universitatii 16, Iasi 700115, Romania, Tel: +40 232 211818, +40 232 301603,

Fax: +40 232 211820, e-mail : rectorat@umfiasi.ro , Fiscal code 4701100.

 

Contact person:

Eugen Carasevici, MD, PhD, professor of Immunology

Department: Immunology, Laboratory of Immunology and Genetics, Interdisciplinary Platform of Molecular Medicine

Address: Bd. Independentei 1, 700111, Iasi, Romania

Tel/Fax: 40 232 213212

E-mail: kara@iasi.mednet.ro


Description of activity: 

The mission of the Gr.T.Popa University of Medicine and Pharmacy is education and research.

The University has 4 Faculties: Medicine, Pharmacy, Dentistry, Bioengineering, and about 5700 students.

The University has also education departments for master programs, PhD programs and training programs for Residents in Medicine.

Research develops in clinic and fundamental departments and at the level of interdisciplinary platforms and centers.

University centers and platforms are: Center for Research in Classic and Laparoscopic Surgery, Surgery Simulation and Training Center, Physiopharmacology Research Platform and Molecular Medicine Interdisciplinary Platform.

  

Molecular Medicine Interdisciplinary Platform represents an investment in biomedical fundamental research and education.

 

Aim and objectives: to create, support and make work a research device of modern molecular medicine which focuses on molecular biology techniques largely involved in the study of genes, proteins, cells and tissues as well as in the complex interactions between these, interactions which are relevant for the understanding of the normal biologic processes and of the way in which they are disturbed in pathologic conditions.

 

Training capacity:

The platform provide facilities for all biomedical high education teaching stages (license, master, PhD, postdoctoral, residents and specialists). Training and secondment are interdisciplinary and trans-disciplinary oriented by encouraging  a paired mentoring system, a concept referred to as twinning, thus fulfilling the requirement of working interactively and moving freely among disciplines needed to investigate genome function.

 

Present research and diagnostic activity:

Molecular study of BRCA genes’ involvement in genetic predisposition to breast and ovarian cancer;- CYP1A1 and p53 polymorphism study in gynecologic cancers;- Cytokine secretion profile in tuberculosis;- Bcr/abl translocation analysis in acute leukemia;- Flt-3 mutations analysis in acute myeloid leukemias;- Endocan expression in renal tumors;- FcRn receptor expression on glandular epithelia;- Medular microenvironment study in acute and cronic leukemia and multiple myeloma; - Noninvasive prenatal diagnosis by fetal DNA analysis in maternal plasma;- Lymphocyte subsets characterization at the fetal-maternal border; - Molecular diagnosis of genetic forms of mental retardation.

 

Relevant research expertise and track record

List of main Research Projects

(Grants under the direction of Prof. Eugen Carasevici)

 

1992 -1994 -  Subgruppen, Spezifität und Antiumorale Aktivität von naturlichen Killer (NK) Zellen 

(Subtypes, Specificity and anti-tumor activity of natural killer (NK) cells)

Financial support: 50 000 DM (aprox  USD 25 000)

Sponsor: Max-Planck Institute for Immunbiology, Freiburg, Germany

 

1999 – 2002 Apoptosis as a regulatoy factor of the cell cycle in renal and breast cancer

Financial support: USD 320 000

Sponsor: World Bank and Romanian Government,

 

2005 – 2007  - Cytokine secretion profiles in lung tuberculosis management

Financial support: Euros 30 000

Sponsor: Romanian Government, Ministry of Education and Research.

2005-2007 – New cellular and molecular targets in pacient oriented therapy of malignant tumors. A genomic approach.

Financial support: Euros 82 000

Sponsor: Romanian Government, Academy of Medical Sciences.

 

2006 – 2008 – Interdisciplinary Platform of Molecular Medicine

Financial support : Euros 1 100 000

Sponsor : Romanian Government, Ministry of Education and Research.

  

Expertise offered and research interests

 

Keywords specifying the expertise:

systems oncology, biomarkers, intercellular communication and microenvironment, tumor morphological evolution, tumor growth and invasion, angiogenesis.

 

Description of the expertise:

Breast cancer inflammatory infiltrate, Colon cancer and hepatic metastases, Immune function at the decidual-trophoblast interface, Hereditary Breast and Ovarian Cancer (HBOC) families identification and recruitment and genetic counseling of BRCA mutations concerned families, Bone marrow microenvironment in multiple myeloma.

 

Main fields of expertise:

Cell culture, flow-cytometry, immunopfenotyping in hematological malignancies, intracellular cytokine detection, immunohistochemistry and automated microscopy and digital image analysis, histocompatibility HLA-phenotyping, caryotyping, FISH, CISH, immunobiochemistry, DNA extraction and sampling, PCR and RT-PCR, mutiplex-PCR detection of known mutations, DNA sequencing,

 

Experience in international cooperation and partnership:

Ludwig Albert University and Medical Center of Freiburg, Germany

Universite Auvergne, Centre d’Oncologie Moleculaire Jean Perin, Clermont-Ferrand, France, Unite INSERM U774, Lille, France.

 

Research interests:

Cancer microenvironment and tumor morphological evolution, tissue immune control unit in tumor development, lymphoid tissue inducer cells in development and pathology, molecular multi-level interactions of tumor- microenvironment interplay.

 

PUBLICATIONS

(last five years)

 

1.

Complete BRCA mutation screening in breast and ovarian cancer predisposition families from a North-Eastern Romanian population.

Negura L, Uhrhammer N, Negura A, Artenie V, Carasevici E, Bignon YJ.

Fam Cancer. 2010 Jun 22. [Epub ahead of print]

 

2.

Neoangiogenesis in cervical cancer: focus on CD34 assessment.

Ancuţa C, Ancuţa E, Zugun-Eloae F, Carasevici E.

Rom J Morphol Embryol. 2010;51(2):289-94.

 

3.

[Specifics of individual risks in a group of women with genital neoplasms]

Matei M, Negură L, Carasevici E, Azoicăi D.

Rev Med Chir Soc Med Nat Iasi. 2009 Oct-Dec;113(4):1216-21. Romanian

 

4.

Using MLPA for large genomic rearrangements detection in breast cancer predisposition genes.

Negură L, Carasevici E, Artenie V, Negură A.

Rev Med Chir Soc Med Nat Iasi. 2009 Oct-Dec;113(4):1182-90.

 

5.

[Prognostic significance of leukemia-associated phenotype in correlation with other biologic markers in acute myeloid leukemia patients]

Dăscălescu A, Zlei M, Grigore G, Dănăila C, Jitaru D, Carasevici E.

Rev Med Chir Soc Med Nat Iasi. 2009 Oct-Dec;113(4):1176-81. Romanian.

 

6.

[Expression of Ki-67 in bronchial asthma]

Grigoraş CC, Grigoraş A, Mihăescu T, Vereş L, Carasevici E.

Rev Med Chir Soc Med Nat Iasi. 2009 Oct-Dec;113(4):1034-9. Romanian.

 

7.

Immunohistochemical study of colorectal cancer liver metastases: the immune/inflammatory infiltrate.

Giuşcă SE, Zugun FE, Târcoveanu E, Carasevici E, Amălinei C, Căruntu ID.

Rom J Morphol Embryol. 2010;51(1):73-9.

 

8.

Predictive value of cellular immune response in cervical cancer.

Ancuta E, Ancuţa C, Zugun-Eloae F, Iordache C, Chirieac R, Carasevici E.

Rom J Morphol Embryol. 2009;50(4):651-5.

 

9.

Hipoxia-Inducible factor HIF-1alfa: Pharmacogenetic perspective for Bevacizumab therapy.

Roxana-Georgiana Tauser, Florin Zugun-Eloae, Daniela Jitaru, Eugen Carasevici Romanian Review of Laboratory Medicine 2009, vol.16, Nr. 3,: 7-12.

 

10.

Tumor biomarkers in cervical cancer: focus on Ki-67 proliferation factor and E-cadherin expression.

Ancuţa E, Ancuţa C, Cozma LG, Iordache C, Anghelache-Lupaşcu I, Anton E, Carasevici E, Chirieac R.

Rom J Morphol Embryol. 2009;50(3):413-8.

 

11.

[The management of unexplained recurrent abortions. Is immunotherapy an option?]

Constantinescu D, Cozmei C, Dumitraşcu I, Carasevici E.

Rev Med Chir Soc Med Nat Iasi. 2008 Apr-Jun;112(2):371-8. Review. Romanian.

 

12.

[Structural changes of tumor microenvironment in liver metastases of colorectal carcinoma]

Giuşcă SE, Carasevici E, Eloae-Zugun F, Târcoveanu E, Căruntu ID.

Rev Med Chir Soc Med Nat Iasi. 2008 Jan-Mar;112(1):165-73. Romanian.

 

13.

Adipokines involvement in lung function.

Gurzu B, Zugun FE, Costuleanu M, Mihăescu T, Carasevici E, Petrescu G.

Rev Med Chir Soc Med Nat Iasi. 2008 Jul-Sep;112(3):719-25.

 

14.

Th1 and Th2 cytokine response in patients with pulmonary tuberculosis and health care workers occupationally exposed to M. tuberculosis.

Cozmei C, Constantinescu D, Carasevici E, Anisie E, Ungureanu D, Sorete-Arbore A, Gramadă D, Mihăescu T, Croitoru C, Popa D.

Rev Med Chir Soc Med Nat Iasi. 2007 Jul-Sep;111(3):702-9.

 

15.

T cell cytokine patterns in active tuberculosis patients in a northeastern area of Romania.

Carasevici E, Cozmei C, Constantinescu D, Sorete-Arbore A, Grămadă D, Mihăescu T.

Roum Arch Microbiol Immunol. 2006 Jan-Jun;65(1-2):46-52

 

16.

The neonatal Fc receptor (FcRn) expression in the human skin.

Cianga P, Cianga C, Plamadeala P, Branisteanu D, Carasevici E.

Virchows Arch. 2007 Oct;451(4):859-60.

 

17.

Low p27(Kip1)expression is associated with poor prognostic factors in breast carcinomas.

Cianga C, Cianga P, Cozma L, Diaconu C, Carasevici E.

J BUON. 2002 Apr-Jun;7(2):117-20.

 

18.

Sequential phenotype changes in progressive lesions of breast carcinoma.

Cianga C, Cianga P, Plamadeala P, Diaconu C, Carasevici E.

J BUON. 2003 Jul-Sep;8(3):281-4.

 

18.

[Vascular molecular markers for determination of disease free survival (DFS) of breast cancer]

Hopulele D, Zugun-Eloae F, Cozma GL, Carasevici E.

Rev Med Chir Soc Med Nat Iasi. 2006 Oct-Dec;110(4):950-4. Romanian.

 

20.

[Bilateral breast cancer (BBC). Considerations on a series of 20 cases]

Diaconu C, Chifu C, Iftime C, Iftime I, Miron L, Carasevici E, Ferariu D, Cobzeanu C, Crumpei F.

Rev Med Chir Soc Med Nat Iasi. 2006 Oct-Dec;110(4):867-73. Romanian.

 

21.

HLA-A and -B phenotypes associated with tuberculosis in population from north-eastern Romania.

Vasilca V, Oana R, Munteanu D, Zugun F, Constantinescu D, Carasevici E.

Roum Arch Microbiol Immunol. 2004 Jul-Dec;63(3-4):209-21

 

 

 

22.

The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland.

Cianga P, Cianga C, Cozma L, Ward ES, Carasevici E.

Hum Immunol. 2003 Dec;64(12):1152-9.

 

23.

Characterization of trophoblasat cells and decidual lymphocytes isolated from fetal-maternal interface.

Daniela Constantinescu, Carmen Cozmei, Laurette Graziella Cozma, Maria Tepelus, Andreea Chiriac, Eugen Carasevici

J Med Prev (Iasi), 2005, 13 (1-2): 88-97

 

24.

[High values of soluble cytokeratin 18 in breast carcinomas may have different meanings]

Cianga P, Cianga C, Anisie E, Zlei M, Ungureanu D, Munteanu D, Chifu C, Diaconu C, Carasevici E.

Rev Med Chir Soc Med Nat Iasi. 2005 Oct-Dec;109(4):836-40. Romanian.

 

 

25.

[Different phenotypes generated by changes in bcl-2 and p53 expression in breast cancer]

Cianga C, Cianga P, Cozma L, Chifu C, Diaconu C, Carasevici E.

Rev Med Chir Soc Med Nat Iasi. 2005 Oct-Dec;109(4):831-5. Romanian